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I'd like to see George R. R. Martin's Wild Cards series be produced as an HBO series. There's no way it could be made as a movie (or even a trilogy); it's too big.
A re-boot of Relic by Preston Douglas and Lincoln Child (since that movie butchered the source material)...then that movie would serve to start franchise with the lead character - Special Agent Pendergast of the FBI.
Any of Daniel Silva's book that features Gabriel Allon.
(non-fiction) Saturday Night: A Backstage History of Saturday Night Live by Doug Hill and Jeff Weingrad. They could probably only focus on the show's first few years but even that would be an epic and crazy-entertaining: network politics, assemblying the cast, fights with censors, drugs, bigger-than-life personalities, the human tornado that was John Belushi, the pressure that came with turning out the shows and the live broadcasts every week, dealing with fame (the chapter on Chevy Chase's departure could be it's own movie). It would be the movie Studio 60 on the Sunset Strip wanted to be...but couldn't quite get there.
First published in 1997, It's a little dated right now, (it's pre 9/11 and the late Saddam Hussein has a cameo) but I always thought a novel called Knight Hawk by Pat O' Connell would make an interesting action film. It's about a female pilot who goes beserk in a F-15 and threatens to take out NYC. Another female fighter pilot attempts to stop her. If adapted, a few things would be switched about, of course, but it would be the essence oif the book.
No#2 "The Select" (aka The Foundation) by F/ Paul Wilson. Kind of like 'The Firm' for med students. Only they use subliminal messages to get you to think like they do in regards to a contreversial medical program.
No#3 The Night Boat by Robert R. McCammon. Nazi zombies from an old U Boat attack an island in the present day Carribean. Need I say more?